Beilstein J. Org. Chem.2021,17, 2399–2416, doi:10.3762/bjoc.17.157
-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant HyptisbrevipesPoit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of
–Smith cyclopropanation; HyptisbrevipesPoit; ring-closing metathesis; Introduction
HyptisbrevipesPoit. is an invasive plant species belonging to the mint family Lamiaceae [1][2][3][4]. This plant has been reported to originate from tropical America but is now distributed broadly in other tropical
to determine bioactive chemicals in HyptisbrevipesPoit. and isolated six new 5,6-dihydro-α-pyrone derivatives 1–6 along with other known compounds, including a 5,6-dihydro-α-pyrone derivative 7 [11], from the whole plant collected in Tawangmangu village, Indonesia (Figure 1) [4]. These six new
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Graphical Abstract
Figure 1:
Structures of brevipolides A–O (1 – 15).